Dengue fever, a mosquito-borne viral disease has emerged as a major public health concern in Nepal with the incidence of cases significantly increasing in recent years. This study aims to conduct a spatial analysis of dengue clusters in Gandaki Province, Nepal from 2021 to 2024 using secondary data sources to identify the geographical distribution and temporal patterns of dengue outbreaks. The research integrates environmental and socio-economic factors such as temperature, humidity, rainfall, population density and urbanization in conjunction with data from the National Population and Housing Census 2021 and satellite data from MODIS and VIIRS.